Does a Heterochromatic variant affect the Human Reproductive outcome?

To study the association of chromosomal polymorphic variations with recurrent miscarriage. Recurrent miscarriage becomes a problem that affect an increasing number of couples with the frequency of about 1% in the couples who want to conceive. This study is based on comparison of chromosome Heteromorphism in the karyotypes of two groups. The first group with 400 individuals with the history of more than two miscarriages and no live birth and as control group 200 individuals with one or more than one normal child. The study revealed that the frequency of chromosomal abnormalities and variations leading to recurrent miscarriage in couples was 18% Chromosomal rearrangements constituted 27.78% of the cases while heterochromatic variations constituted 72.22% of the chromosomal cause for recurrent miscarriages. In the present study, pericentric inversion of chromosome 9 and heteromorphism of chromosomes 1 were the most common findings. Present study indicates that there is need to evaluate the known heterochromatic variants as these variants play an important role in pregnancy loss.